Pseudomonas aeruginosa lasR Transcription Correlates with the Transcription of lasA , lasB , and toxA in Chronic Lung Infections Associated with Cystic Fibrosis

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Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis.

The role of Pseudomonas aeruginosa quorum-sensing systems in the lung infections associated with cystic fibrosis (CF) has not been examined. The purpose of this study was to determine if genes regulated by the LasR-LasI quorum-sensing system were coordinately regulated by the P. aeruginosa populations during the lung infections associated with CF. We also wanted to ascertain if there was a rela...

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Pseudomonas aeruginosa chronic lung infections are the major cause of morbidity and mortality associated with cystic fibrosis. For many years, the consensus was that cystic fibrosis patients acquire P. aeruginosa from the environment, and hence harbour their own individual clones. However, in the past 15 yrs the emergence of transmissible strains, in some cases associated with greater morbidity...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1998

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.66.6.2521-2528.1998